2012 ACCF/ AHA/ ACP/ AATS/ PCNA/ SCAI/ STS Guideline for the Diagnosis and Management of Patients With Stable Ischemic Heart Disease

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JACC: 11/20/12 The  medical profession should play a central role in evaluating the evidence related to drugs, devices, and procedures for the detection, management, and prevention of disease. When properly applied, expert analysis of available data on the benefits and risks of these therapies and procedures can improve the quality of care, optimize patient outcomes, and favorably […]

A Population-Based Study of Hospital Care Costs During 5 Years After Transient Ischemic Attack and Stroke

AHA: 11/15/12 Background and Purpose—Few studies have evaluated long-term costs after stroke onset, with almost no cost data for transient ischemic attack (TIA). We studied hospital costs during the 5 years after TIA or stroke in a population-based study. Methods—Patients from a United Kingdom population-based cohort study (Oxford Vascular Study) were recruited from 2002 to […]

Trends in Substance Abuse Preceding Stroke Among Young Adults

AHA: November 15, 2012 Background and Purpose—Approximately 5% of strokes occur in adults aged 18 to 44 years. Substance abuse is a prevalent risk factor for stroke in young adults. We sought to identify trends in substance abuse detection among stroke patients. Methods—Using a population-based design, we sought to identify all patients aged 18 to […]

Soft drink intake in relation to incident ischemic heart disease, stroke, and stroke subtypes in Japanese men and women: the Japan Public Health Centre–based study cohort I

Ajcn: 10/17/12 Background: Soft drink intake has been associated with obesity and diabetes, but its relation with risk of cardiovascular disease (CVD) is limited. Objective: We examined the association between soft drink intake and risk of CVD in a Japanese population. Design: This was a prospective study in 39,786 Japanese men and women aged 40–59 y in which soft […]

The A’s and B’s of the ABC’s of stroke mechanisms and recurrence in pediatric ischemic stroke

Neurology: 10/17/12 Arterial ischemic stroke in children is rare, estimated at 2 per 100,000 children per year,1 but carries a relatively high risk of both recurrent stroke and lifelong neurologic morbidity.2 Ischemic stroke mechanisms in both adults and children can be conceptually broken down into the “ABCs”: arterial, blood, and cardiac. The mechanism of the stroke is important […]

Higher coated-platelet levels are associated with stroke recurrence following nonlacunar brain infarction

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Nature: 11/14/12 Coated-platelets are procoagulant platelets observed upon dual-agonist stimulation with collagen and thrombin. Coated-platelet levels are elevated in patients with nonlacunar (large-vessel) ischemic stroke and decreased in patients with spontaneous intracerebral hemorrhage as compared with controls. The purpose of this study was to investigate a possible relationship between coated-platelet levels and stroke recurrence in patients […]

Assessment of leptomeningeal collaterals using dynamic CT angiography in patients with acute ischemic stroke

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Nature: 11/14/12 Whole-brain dynamic time-resolved computed tomography angiography (CTA) is a technique developed on the new 320-detector row CT scanner capable of generating time-resolved cerebral angiograms from skull base to vertex. Unlike a conventional cerebral angiogram, this technique visualizes pial arterial filling in all vascular territories, thereby providing additional hemodynamic information. Ours was a retrospective study […]

Analysis of a Coordinated Stroke Center and Regional Stroke Network on Access to Acute Therapy and Clinical Outcomes

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American Heart Association: 11/13/12 Background and Purpose—Compare access and outcomes in a tertiary care community hospital (Saint Luke’s Neuroscience Institute) and its stroke network to hospitals in 3 national databases. Methods—Retrospective analysis of ischemic stroke patients (2005, 2007, 2010) in Saint Luke’s (n=1576), Get With The Guidelines-Stroke (n=423 809), Premier (n=91 598), and Merci Registry (n=966). […]

Lifestyle Risk Factors for Ischemic Stroke and Transient Ischemic Attack in Young Adults in the Stroke in Young Fabry Patients Study

American Heart Association: November 13, 2012 Background and Purpose—Although many stroke patients are young or middle-aged, risk factor profiles in these age groups are poorly understood. Methods—The Stroke in Young Fabry Patients (sifap1) study prospectively recruited a large multinational European cohort of patients with cerebrovascular events aged 18 to 55 years to establish their prevalence of […]

The PLAN Score A Bedside Prediction Rule for Death and Severe Disability Following Acute Ischemic Stroke

 JAMA: Nov 12, 2012 We sought to develop and validate a simple clinical prediction rule for death and severe disability after acute ischemic stroke that can be used by general clinicians at the time of hospital admission. Methods  We analyzed data from a registry of 9847 patients (4943 in the derivation cohort and 4904 in […]

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