Advanced imaging improves prediction of hemorrhage after stroke thrombolysis

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Wiley: 1/1/12 Objective: Very low cerebral blood volume (VLCBV), diffusion and hypoperfusion lesion volumes have been proposed as predictors of hemorrhagic transformation following stroke thrombolysis. We aimed to compare these parameters, validate VLCBV in an independent cohort using DEFUSE study data and investigate the interaction of VLCBV with regional reperfusion. Methods: The EPITHET and DEFUSE studies […]

Ischaemic stroke is associated with the ABO locus: The euroclot study

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Wiley: 1/1/12 Objectives End-stage coagulation and the structure/function of fibrin are implicated in the pathogenesis of ischaemic stroke. We explored whether genetic variants associated with end-stage coagulation in healthy volunteers account for the genetic predisposition to ischemic stroke and examined their influence on stroke subtype. Methods Common genetic variants identified through genome-wide association studies of coagulation […]

Reliability of brain CT evaluation by stroke neurologists in telemedicine

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Neurology: December 19, 2012 Objective: To determine the reliability and therapeutic impact of standardized cerebral CT evaluation and quantification of early ischemic changes (EIC) with the Alberta Stroke Program Early CT Score (ASPECTS) by stroke neurologists in the Stroke Eastern Saxony Network (SOS-NET), which provides telemedical consultations for patients with acute ischemic stroke. Methods: Two neuroradiologists re-evaluated all […]

Independent predictors of ischemic stroke in the elderly Prospective data from a stroke unit

Neurology: December 12, 2012 Objective: Incidence of ischemic stroke (IS) increases with age. Knowledge of factors associated with IS acute outcomes in the oldest-old (≥80 years) is needed to improve quality of care and resource allocation in this age group. Methods: Data are for 769 consecutive IS patients aged ≥60 years (436 aged ≥80 years) admitted to an […]

Stroke After Carotid Stenting and Endarterectomy in the Carotid Revascularization Endarterectomy Versus Stenting Trial (CREST)

AHA: November 16, 2012 Background—Stroke occurs more commonly after carotid artery stenting than after carotid endarterectomy. Details regarding stroke type, severity, and characteristics have not been reported previously. We describe the strokes that have occurred in the Carotid Revascularization Endarterectomy versus Stenting Trial (CREST). Methods and Results—CREST is a randomized, open-allocation, controlled trial with blinded […]

Relation of Gender-Specific Risk of Ischemic Stroke in Patients With Atrial Fibrillation to Differences in Warfarin Anticoagulation Control (from AFFIRM)

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American Journal of Cardiology: 12/15/12 Warfarin decreases risk of stroke for patients with atrial fibrillation (AF) dependent on percent time in the therapeutic range (TTR) with an international normalized ratio (INR) of 2 to 3. We hypothesized that gender differences in ischemic stroke risk are related to TTR. From the AFFIRM database of 4,060 patients with […]

Heart Disease and Stroke Statistics

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AHA: 12/12/12 Each year, the American Heart Association (AHA), in conjunction with the Centers for Disease Control and Prevention, the National Institutes of Health, and other government agencies, brings together the most up-to-date statistics on heart disease, stroke, other vascular diseases, and their risk factors and presents them in its Heart Disease and Stroke Statistical […]

Patient refusal of thrombolytic therapy for suspected acute ischemic stroke

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Wiley: 12/11/12 Patients who were treated with and refused t-PA at our stroke center were identified retrospectively. Demographics, clinical presentation, and outcome measures were collected and compared. Clinical outcome was defined as excellent (mRS: 0–1), good (mRS: 0–2), and poor (mRS: 3–6). Results Over 7·5 years, 30 (4·2%) patients refused t-PA. There were no demographic differences […]

Adherence to Hospital Discharge Medication in Patients With Ischemic Stroke

AHA: 12/6/12 Background and Purpose—Communication between hospitals and primary care physicians is essential for the continuity of care for patients being transferred from hospital to ambulatory care. Patients are often discharged from hospital on medication regimes different from those used before hospital admission. The aim of the study was to evaluate the adherence to hospital discharge […]

Relation of the Traditional Mediterranean Diet to Cerebrovascular Disease in a Mediterranean Population

Oxford Journals: 11/27/12 The authors aimed to evaluate the association of the traditional Mediterranean diet and major food groups with incidence of and mortality from cerebrovascular disease (CBVD) in a Mediterranean population. The study population was a cohort of 23,601 participants from the Greek segment of the EPIC Study (European Prospective Investigation into Cancer and Nutrition) […]

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