Profiles of the National Institutes of Health Stroke Scale Items as a Predictor of Patient Outcome

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STROKEAHA:  May 23, 2013 Background and Purpose—Initial National Institutes of Health Stroke Scale (NIHSS) score is highly predictive of outcome after ischemic stroke. We examined whether grouping strokes by presence of individual NIHSS symptoms could provide prognostic information additional or alternative to the NIHSS total score. Methods—Ischemic strokes from the Greater Cincinnati Northern Kentucky Stroke […]

Low Dehydroepiandrosterone Sulfate is Associated With Increased Risk of Ischemic Stroke Among Women

NativeHawaiian

STROKEAHA:  May 23, 2013 Background and Purpose—Previous research suggests greater risk of coronary heart disease with lower levels of the adrenal steroid dehydroepiandrosterone sulfate (DHEAS). No studies have examined the association between DHEAS and risk of ischemic stroke. DHEAS may influence ischemic stroke risk through atherosclerotic-related mechanisms (endothelial function and smooth muscle cell proliferation) or […]

Cannabis, Ischemic Stroke, and Transient Ischemic Attack

reserachman

STROKEAHA: May 21, 2013 Background and Purpose—There is a temporal relationship between cannabis use and stroke in case series and population-based studies. Methods—Consecutive stroke patients, aged 18 to 55 years, who had urine screens for cannabis were compared with a cohort of control patients admitted to hospital without cardiovascular or neurological diagnoses.  Read more

Racial and Ethnic Differences in Outcomes in Older Patients With Acute Ischemic Stroke

CIRCOUTCOMES: May 16, 2013 Background—Little is known as to whether long-term outcomes of acute ischemic stroke (AIS) vary by race/ethnicity. Using the American Heart Association Get With The Guidelines–Stroke registry linked with Medicare claims data set, we examined whether 30-day and 1-year outcomes differed by race/ethnicity among older patients with AIS. Methods and Results—We analyzed 200 […]

Influence of Chronic Ethanol Consumption on the Neurological Severity in Patients With Acute Cerebral Ischemia

STROKEAHA: May 16, 2013 Background and Purpose—We tested the hypothesis that excessive chronic ethanol consumption is associated with more severe ischemic strokes. Methods—We recruited patients with supratentorial cerebral ischemia within 48 hours of symptom onset. We defined heavy drinkers by a weekly consumption of ethanol of ≥300 g and severe strokes by a National Institutes of […]

Immunohistochemical Analysis of Thrombi Retrieved During Treatment of Acute Ischemic Stroke

Patient

STROKEAHA: May 14, 2013 Background and Purpose—To provide evidence whether mechanical thrombectomy with stent-retrievers in the treatment of acute ischemic stroke causes intimal damage. Methods—This study analyzed thrombi retrieved by mechanical thrombectomy from cerebral arteries in 48 consecutive patients with acute ischemic stroke for the presence of endothelial cells using CD34 antibodies. Read more

17q25 Locus Is Associated With White Matter Hyperintensity Volume in Ischemic Stroke, But Not With Lacunar Stroke Status

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STROKEAHA: May 14, 2013 Background and Purpose—Recently, a novel locus at 17q25 was associated with white matter hyperintensities (WMH) on MRI in stroke-free individuals. We aimed to replicate the association with WMH volume (WMHV) in patients with ischemic stroke. If the association acts by promoting a small vessel arteriopathy, it might be expected to also associate […]

In Vivo Measurement of Oxygenation Changes after Stroke Using Susceptibility Weighted Imaging Filtered Phase Data

digitalrecords

PLOS One: May 13, 2013 Background and Purpose Cerebral blood oxygenation level is critical for following the evolution of stroke patients. The purpose of this study was to investigate the feasibility of measuring changes in blood oxygen levels for patients with acute stroke using SWI and to compare these changes with the patient’s recovery over […]

Transcranial Laser Therapy and Infarct Volume

STROKEAHA: May 9, 2013 Background and Purpose—Two randomized trials suggested that transcranial laser therapy (TLT) may benefit patients with acute ischemic stroke, although efficacy has not been confirmed. Supportive proof of concept could be demonstrated if TLT reduces the volume of cortical infarction. Methods—The NeuroThera Efficacy and Safety Trial-2 (NEST-2) was a randomized trial of TLT […]

Long- and Short-term Weight Change and Incident Coronary Heart Disease and Ischemic Stroke

Am. J. Epidemiology: May 3 2013 Weight gain increases the prevalence of obesity, a risk factor for cardiovascular disease. Nevertheless, unintentional weight loss can be a harbinger of health problems. The Atherosclerosis Risk in Communities Study (1987–2009) included 15,792 US adults aged 45–64 years at baseline and was used to compare associations of long-term (30 […]

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