Risk–Benefit Profile of Long-Term Dual- Versus Single-Antiplatelet Therapy Among Patients With Ischemic Stroke: A Systematic Review and Meta-analysis

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Annals: October 2013 Background: Dual-antiplatelet regimens for prevention of recurrent stroke promote antithrombotic effects but may increase the risk for hemorrhage. Purpose: To qualitatively and quantitatively examine the risk for recurrent stroke and intracranial hemorrhage (ICH) linked to long-term dual- and single-antiplatelet therapy among patients with ischemic stroke and transient ischemic attack. Data Sources: PubMed, EMBASE, and the Cochrane Central […]

Twenty-Year Trends in Long-term Mortality Risk in 17 149 Survivors of Ischemic Stroke Less Than 55 Years of Age

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STROKEAHA: October 1, 2013 Background and Purpose—The purpose of the present study was to investigate the 4-year mortality risk among patients <55 years with a first ischemic stroke during 1987–2006. Methods—A total of 17 149 cases (37.4% women) aged 18 to 54 years who survived ≥28 days after a first ischemic stroke were identified in the […]

Intravenous Tissue Plasminogen Activator Administration in Community Hospitals Facilitated by Telestroke Service

Neurosurgery: October 2013 BACKGROUND: Stroke is a leading cause of death and disability in the United States. Despite the proven benefits of intravenous tissue plasminogen activator (IV-tPA), only a small percentage of patients who have had a stroke (3.4%–5.2%) receive this US Food and Drug Administration-approved therapy. OBJECTIVE: To prospectively assess the impact of a telestroke […]

Posterior circulation ischaemic stroke and transient ischaemic attack: diagnosis, investigation, and secondary prevention

he Lancet Neurology: October 2013 A fifth of all strokes and transient ischaemic attacks occur in the posterior circulation arterial territory. Diagnosis can be challenging, in part because of substantial overlap in symptoms and signs with ischaemia in the anterior circulation. Improved methods of non-invasive imaging of the vertebrobasilar arterial tree have been used in recent […]

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