Effect of treatment delay, age, and stroke severity on the effects of intravenous thrombolysis with alteplase for acute ischaemic stroke: a meta-analysis of individual patient data from randomised trials

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The Lancet: 6 August 2014 Background Alteplase is effective for treatment of acute ischaemic stroke but debate continues about its use after longer times since stroke onset, in older patients, and among patients who have had the least or most severe strokes. We assessed the role of these factors in affecting good stroke outcome in patients […]

Current practices in feeding tube placement for US acute ischemic stroke inpatients

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Neurolog: August 6, 2014 Objective: We sought to identify current US hospital practices for feeding tube placement in ischemic stroke. Methods: In a retrospective observational study, we examined the frequency of feeding tube placement among hospitals in the Nationwide Inpatient Sample with ≥30 adult ischemic stroke admissions annually with length of stay greater than 3 days. We examined […]

The Evolution and Future of ACC/AHA Clinical Practice Guidelines: A 30-Year Journey

Ischemic Stroke

JACC: August 2014 A Report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines Read More

Systolic Blood Pressure Levels Among Adults With Hypertension and Incident Cardiovascular Events

JAMA: August 2014 Importance  Studies document a progressive increase in heart disease risk as systolic blood pressure (SBP) rises above 115 mm Hg, but it is unknown whether an SBP lower than 120 mm Hg among adults with hypertension (HTN) lowers heart failure, stroke, and myocardial infarction risk. Objective  To examine the risk of incident cardiovascular (CV) […]

Characteristic Adverse Events and Their Incidence Among Patients Participating in Acute Ischemic Stroke Trials

STROKEAHA: July 31, 2014 Background and Purpose—Adverse events (AE) in trial populations present a major burden to researchers and patients, yet most events are unrelated to investigational treatment. We aimed to develop a coherent list of expected AEs, whose incidence can be predicted by patient characteristics that will inform future trials and perhaps general poststroke care. […]

Republished: Society for Neuroscience in Anesthesiology and Critical Care Expert Consensus Statement: Anesthetic Management of Endovascular Treatment for Acute Ischemic Stroke*

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STROKEAHA: 8/1/14 Literature on the anesthetic management of endovascular treatment of acute ischemic stroke (AIS) is limited. Anesthetic management during these procedures is still mostly dependent on individual or institutional preferences. Thus, the Society of Neuroscience in Anesthesiology and Critical Care (SNACC) created a task force to provide expert consensus recommendations on anesthetic management of endovascular […]

Loss of the Mexican American Survival Advantage After Ischemic Stroke

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STROKEAHA:  July 29, 2014 Background and Purpose—Mexican Americans (MAs) were previously found to have lower mortality after ischemic stroke than non-Hispanic whites. We studied mortality trends in a population-based design. Methods—Active and passive surveillance were used to find all ischemic stroke cases from January 2000 to December 2011 in Nueces County, TX. Deaths were ascertained from […]

Symptomatic Intracerebral Hemorrhage in Acute Ischemic Stroke After Thrombolysis With Intravenous Recombinant Tissue Plasminogen Activator

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JAMA: July 28, 2014 Importance  Intravenous thrombolysis remains the mainstay treatment for acute ischemic stroke. One of the most feared complications of the treatment is thrombolysis-related symptomatic intracerebral hemorrhage (sICH), which occurs in nearly 6% of patients and carries close to 50% mortality. The treatment options for sICH are based on small case series and expert opinion, and the […]

Impact of State Medicaid Coverage on Utilization of Inpatient Rehabilitation Facilities Among Patients With Stroke

 AHA: July 8, 2014 Background and Purpose—Poststroke rehabilitation is associated with improved outcomes. Medicaid coverage of inpatient rehabilitation facility (IRF) admissions varies by state. We explored the role of state Medicaid IRF coverage on IRF utilization among patients with stroke. Methods—Working age ischemic stroke patients with Medicaid were identified from the 2010 Nationwide Inpatient Sample. […]

Ensuring the Future of Clinical and Basic Stroke Research

STROKEAHA: July 8, 2014 The stroke field has seen tremendous progress regarding both clinical and basic research advances over the past several decades. Preclinical stroke research has identified the major components of the ischemic cascade that contribute to the death of ischemic brain tissue and the important interactions between neuronal, glial, and endothelial cells not only […]

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