Statin Therapy and Outcome After Ischemic Stroke
Stroke Reports Saturday, January 26th, 2013STROKEAHA: January 3, 2013
Systematic Review and Meta-Analysis of Observational Studies and Randomized Trials
Background and Purpose—Although experimental data suggest that statin therapy may improve neurological outcome after acute cerebral ischemia, the results from clinical studies are conflicting. We performed a systematic review and meta-analysis investigating the relationship between statin therapy and outcome after ischemic stroke.
Methods—The primary analysis investigated statin therapy at stroke onset (prestroke statin use) and good functional outcome (modified Rankin score 0 to 2) and death. Secondary analyses included the following: (1) acute poststroke statin therapy (≤72 hours after stroke), and (2) thrombolysis-treated patients. Read more