Unequal Access to Treatment With Intravenous Alteplase for Women With Acute Ischemic Stroke

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STROKEAHA:  July 25, 2013 Background and Purpose—A recent meta-analysis showed that women with acute ischemic stroke are less likely to receive treatment with intravenous alteplase than men. The aim of this study was to assess sex differences in treatment with intravenous alteplase and to explore the reasons for these differences. Methods—We analyzed data from the Promoting […]

Relationship Between Onset-to-Door Time and Door-to-Thrombolysis Time

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STROKEAHA: July 25, 2013   A Pooled Analysis of 10 Dedicated Stroke Centers Background and Purpose—Inverse relationship between onset-to-door time (ODT) and door-to-needle time (DNT) in stroke thrombolysis was reported from various registries. We analyzed this relationship and other determinants of DNT in dedicated stroke centers. Methods—Prospectively collected data of consecutive ischemic stroke patients from 10 […]

Predicting Clinical Outcomes After Thrombolysis Using the iScore

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STROKEAHA: July 25, 2013 Background and Purpose—The ischemic stroke risk score (iScore) is a validated tool developed to estimate the risk of death and functional outcomes early after an acute ischemic stroke. Our goal was to determine the ability of the iScore to estimate clinical outcomes after intravenous thrombolysis tissue-type plasminogen activator (tPA) in the Virtual […]

Persistent ischemic stroke disparities despite declining incidence in Mexican Americans

Wiley:  7/19/13 OBJECTIVE: To determine trends in ischemic stroke incidence among Mexican Americans and non Hispanic Whites. METHODS: We performed population-based stroke surveillance from January 1, 2000 – December 31, 2010 in Corpus Christi, Texas. Ischemic stroke cases 45 years and over were ascertained from potential sources and charts abstracted. Neurologists validated cases based on […]

Ideal Cardiovascular Health Metrics and the Risks of Ischemic and Intracerebral Hemorrhagic Stroke

STROKEAHA: July 18, 2013 ackground and Purpose—Previous studies showed an inverse association between ideal cardiovascular health (CVH) metrics and the total risk of cardiovascular diseases and stroke. This study aimed to investigate the relationship between ideal CVH metrics and the risks of ischemic and hemorrhagic stroke, respectively. Methods—We collected information on the 7 ideal CVH metrics […]

Overlap of Diseases Underlying Ischemic Stroke

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STROKEAHA: 7/16/13 Background and Purpose—ASCOD phenotyping (A, atherosclerosis; S, small vessel disease; C, cardiac pathology; O, other causes; and D, dissection) assigns a degree of likelihood to every potential cause (1 for potentially causal, 2 for causality is uncertain, 3 for unlikely causal but disease is present, 0 for absence of disease, and 9 for insufficient […]

Epidemiology of stroke and its subtypes in Chinese vs white populations

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Neurology: July 16, 2013 Objective: We aimed to systematically assess the evidence for differences in the incidence of stroke and distribution of its subtypes in Chinese compared with white populations. Methods: We comprehensively sought studies conducted since 1990 in Chinese populations of 1) first-ever stroke incidence (community-based studies only), and 2) pathologic types/subtypes of stroke (hospital- or community-based […]

Comparison of the response to endovascular reperfusion in relation to site of arterial occlusion

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Neurology: 7/12/13 Objective: We explored the relationship between the site of vascular occlusion and the response to endovascular treatment in patients with acute ischemic stroke and also considered the impact of mismatch profile. Methods: DEFUSE-2 was a prospective cohort study of patients treated with endovascular therapy. Patients with internal carotid artery (ICA) and middle cerebral artery (MCA) involvement […]

Results of Intravenous Thrombolysis Within 4.5 to 6 Hours and Updated Results Within 3 to 4.5 Hours of Onset of Acute Ischemic Stroke Recorded in the Safe Implementation of Treatment in Stroke International Stroke Thrombolysis Register (SITS-ISTR) An Observational Study

JAMA Neurol: 7/1/13 Importance  Pooled analysis of randomized controlled trials of intravenous thrombolysis shows no statistically significant benefit beyond 4.5 hours, with the possible advantage perhaps offset by risk. Objective  To compare the outcomes of patients who were treated within 4.5 to 6 hours or within 3 to 4.5 hours of the onset of an ischemic stroke with […]

A simple 8-point score strongly predicts early outcomes in acute stroke

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Wiley:  7/9/13 Previous prognostic scoring systems in predicting stroke mortality are complex, require multiple measures that vary with time and failed to produce a simple scoring system. Aims/Hypothesis The study aims to derive and internally validate a stroke prognostic scoring system to predict early mortality and hospital length of stay. Read More

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